Effect of Low-Level Electrical Stimulation of the Arotic Root Ventricular Ganglionated Plexi on Electrical and Structural Remodling in Dogs with Heart Failure
نویسندگان
چکیده
The rise of vagal tone facilitated the activity of pulmonary veins and played an important role in the initiation of AF [1]. Autonomic nerve stimulation shortens AERP, decreases the wavelength of atrial reentrant circuits and increases dAERP, thus, promoting the stability of AF [2]. Several studies have demonstrated that additional ablation of epicardiol ganglionated plexi (GP) improved success rate in catheter ablation of AF after circumferential isolation of pulmonary veins [3,4]. But in long term follow-up, the effect of GP ablation is limited due to high reoccurance rate of AF [5,6].
منابع مشابه
Low-Level Electrical Stimulation of Aortic€Root Ventricular Ganglionated Plexi€Attenuates Autonomic Nervous System–Mediated Atrial Fibrillation
METHODS Effective refractory periods (ERPs) of test pulmonary veins (PVs) were measured at baseline and during highlevel (HL-ES) and low-level (LL-ES) electrical stimulation of the aortic root GP. The arrhythmogenic threshold of acetylcholine and isoproterenol was determined at baseline and during HL-ES and LL-ES. Moreover, AF was induced at PVs by programmed electrical stimulation after HL-ES ...
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An autonomic imbalance, i.e., increased sympathetic tone and/or decreased parasympathetic tone is a critical characteristic of heart failure, which is associated with progressive ventricular remodeling, ventricular arrhythmia generation and disease progression. Increasing cardiac parasympathetic tone by vagus nerve stimulation has been shown to significantly improve heart failure symptoms, hemo...
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BACKGROUND Ganglionated plexi (GP) ablation has been shown to play an important role in atrial fibrillation (AF) initiation and maintenance. Also, GP ablation increases chances for prevention of AF recurrence. This study investigated the effects of GP ablation on ventricular electrophysiological properties in normal dog hearts and after acute myocardial ischemia (AMI). METHODS Fifty anestheti...
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INTRODUCTION: Left atrial ganglionated plexi ablation is an adjuvant technique used to increase the success rate of surgical ablation of atrial fibrillation. Ganglionated plexi ablation requires previous detection. We aimed to assess determinants of successful ganglionated plexi detection and to correlate range of ganglionated plexi ablation with risk of early atrial fibrillation recurrence. ...
متن کاملAnti-arrhythmic effects of atrial ganglionated plexi stimulation is accompanied by preservation of connexin43 protein in ischemia-reperfusion canine model.
BACKGROUND Vagal nerve stimulation (VNS) has been shown to provide a protective effect against ischemia/reperfusion (I/R)-related arrhythmias by preventing the loss of Connexin43 (Cx43). Our previous studies showed that atrial epicardial ganglionated plexus stimulation (GPS) might exert a VNS-like effect on ventricular electrophysiology. OBJECTIVES To investigate whether GPS could preserve Cx...
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